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1 edition of Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy found in the catalog.

Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy

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Published by INTECH Open Access Publisher .
Written in English


Edition Notes

En.

ContributionsYuko Maezawa, author
The Physical Object
Pagination1 online resource
ID Numbers
Open LibraryOL27075768M
ISBN 109535103598
ISBN 109789535103592
OCLC/WorldCa884215722

18F-fluorocholine PET-MR Imaging of Coronary Plaque Vulnerability The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. gated coronary plaque morphology looking at possible differences in plaque vulnerability between men and women with stable CAD. Patients and methods We retrospectively collected and analyzed clinical data and coronary plaque morphology by frequency-domain optical coherence tomography in men and women with stable CAD. Results A total of ( were in men and 42 in women) plaques from that this new imaging modality is capable of accurately characterizing the structure and composition of normal vessels and atherosclerotic plaques,34 36 OCT catheters, suitable for intravascular application, have recently been developed and applied for imaging coronary arteries in patients. In vivo OCT imaging is facilitated by an 8–. “Molecular Imaging of Inflamed Atherosclerotic Plaque with 18F-anti-VCAM-1 Nanobody and PET/CT.” In Eur Heart J Cardiovasc Imaging Abstracts Supplement. Vancouver. 1. Bala G, Blykers A, Xavier C, Gillis K, Tierens S, Descamps B, et al. Molecular imaging of inflamed atherosclerotic plaque with 18F-anti-VCAM-1 nanobody and PET/CT. Eur Heart J Cited by: 1.

Coronary computed tomographic angiography (CCTA) is emerging as a key noninvasive method for assessing cardiovascular risk by measurement of coronary stenosis and coronary artery calcium (CAC). New advancements in CCTA technology have led to the ability to directly identify and quantify the so-called "vulnerable" plaques that have features of Cited by:


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Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy by Yasumi Uchida Download PDF EPUB FB2

Fluorescence in 57 excised human coronary plaques was examined by A-imaging color fluorescent angioscopy. Oxidized LDL in 31 excised coronary plaques and in 12 plaques of 7 patients was. Yasumi Uchida and Yuko Maezawa (March 16th ). Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy, Molecular Imaging, Bernhard Schaller, IntechOpen, DOI: / Available from:Cited by: 7.

Uchida Y, Maezawa Y () Molecular imaging of atherosclerotic coronary plaques by fluorescent angioscopy. In: Schaller B (ed) Molecular Imaging, InTec Cited by:   Objectives This study was carried out to detect vulnerable coronary plaques by color fluorescent angioscopy.

Background Collagen fibers (CFs) mainly provide mechanical support to coronary plaques. Oxidized low-density lipoprotein (Ox-LDL) induces macrophage proliferation, which in turn destroy CFs while accumulating lipids.

As such, demonstration of the absence of CFs, deposition Cited by: The color fluorescence of the major substances that constitute atherosclerotic plaques () was examined by color fluorescent microscopy (CFM) system (IX 70, Olympus Co., Tokyo, Japan) using a ± nm band-pass filter (BPF), a nm dichroic membrane (DM), and a nm band-absorption filter (BAF).This combination of BPF, DM, and BAF for A-imaging of fluorescence was Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy book because Cited by:   Imaging of Triglycerides in Human Coronary Plaques by Color Fluorescent Angioscopy and Microscopy.

Uchida Y(1), Uchida Y(2), Hiruta N(3), Shirai S(4), Yoshida T(5). Author information: (1)Japan Foundation for Cardiovascular Research, Funabashi, Japan; Department of Cardiology, Tokyo Jikei University School of Medicine, Tokyo, by: 1.

Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy. By Yasumi Uchida and Yuko Maezawa. Open access peer-reviewed. Molecular Imaging of Tumor Angiogenesis. By Shaunagh McDermott and Alexander Guimaraes.

Open access peer-reviewed. PET and SPECT Imaging of Tumor Angiogenesis. This study was carried out to detect vulnerable coronary plaques by color fluorescent angioscopy. Collagen fibers (CFs) mainly provide mechanical support to coronary plaques.

Molecular Imaging of Apolipoprotein B in Human Coronary Plaques by Color Fluorescent Angioscopy and Microscopy. However, its localization in human Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy book plaques is not well understood.

The present study was performed to visualize ApoB in human coronary artery by: 6. Purpose of Review: In vivo imaging of the native substances, including lipoproteins, that comprise human atherosclerotic plaques is currently beyond the scope of any available imaging techniques.

Color and near-infrared fluorescent angioscopy (CFA and NIRFA, respectively) systems have been recently developed for molecular imaging of lipoproteins within the human coronary arterial wall ex vivo Cited by: 6.

Detection of Atherosclerotic Coronary Plaques by Fluorescence Lifetime Imaging Angioscopy. (August ) Patrick Allen Thomas, B.S., Louisiana Tech University Chair of Advisory Committee: Dr.

Javier Jo Vulnerable plaque is a clinically silent condition of atherosclerotic plaque that leaves a large number of patients at risk of a coronary event. Written by Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy book distinguished pioneer in the history and development of coronary angioscopic techniques, Coronary Angioscopy is the Molecular Imaging of Atherosclerotic Coronary Plaques by Fluorescent Angioscopy book and only book to systematically describe the present status of percutaneous coronary angioscopy and cardioscopy.

Cardiologists and other interested physicians will value its clear explanations of the pathophysiology of coronary artery diseases, as well as the. Maria Drakopoulou, Dimitris Tousoulis, in Coronary Artery Disease, Angioscopy.

Angioscopy is an invasive imaging modality that evaluates the luminal surface by direct visualization of the interior of blood vessels [92].Atherosclerotic plaques are seen as well-demarcated white, yellow or orange protrusions into the lumen.

Coronary angioscopy or cardioscopy using biocompatible markers is one choice for evaluation of tissues, cells, or molecules which comprise the target lesions. Angioscopy using EB as a biomarker, namely, dye-staining angioscopy, has been developed and applied for molecular imaging of the substances that constitute atherosclerotic : Takanobu Tomaru, Fumitaka Nakamura, Yoshiharu Fujimori, Yasumi Uchida.

3 Molecular imaging of coronary plaques Traditionally, atherosclerotic coronary artery disease was only diagnosed at advanced stages by determining the degree of lumen stenosis or by myocardial perfusion assessment.

However, molecular imaging modalities en-able assessment of coronary artery disease down to the cellular and molecular level. Molecular Imaging of Coronary Plaques Daniel S. Berman, MD Director, Cardiac Imaging Cedars-Sinai Heart Institute CSMC Professor of Medicine David Geffen School of Medicine at UCLA Zahi A.

Fayad, PhD, FAHA, FACC PfProfessor of RdilRadiology and MMdiiedicine (C di l)(Cardiology) Director, Translational and Molecular Imaging Institute. The composition of atherosclerotic plaques is an important determinant in the progression of thrombus-mediated acute coronary syndromes.

1 Thin-cap fibroatheromas (TCFAs) comprise the majority of coronary plaques implicated in acute coronary events. 2,3 TCFAs consist of a thin fibrous cap (minimum cap thickness Cited by: Atherosclerotic Plaque Characterization Methods Based on Coronary Imaging: Medicine & Health Science Books @ The composition of atherosclerotic plaques in the coronary arteries displays substantial variability and is associated with the likelihood for rupture and downstream ischemic events.

Accurate identification and quantification of coronary plaque components on CT is challenging because of the limited temporal, spatial, and contrast resolutions of Cited by: atherosclerotic activity and plaque vulnerability.

Currently, multidetector CT is capable of the noninvasive detection of coronary stenosis and coronary calcifications. High resolution CT may be beneficial in the detection of noncalcified vulnerable coronary plaques, and more reliable with the use of newer high-speed volume CT scanners. Molecular Imaging of High-Risk Atherosclerotic Plaques high-risk atherosclerotic plaques have translated clinically.

In this review, we will focus on the clinical translatability of molecular imaging of atherosclerosis. First, ideal targets for imaging high-risk atherosclerotic plaques will be briefly dis-cussed. Multiphoton microscopy using laser sources in the mid-infrared range (MIR, 1, nm and 1, nm) was used to image atherosclerotic plaques from murine and human samples.

Third harmonic generation (THG) from atherosclerotic plaques revealed morphological details of cellular and extracellular lipid deposits.

Simultaneous nonlinear optical signals from the same laser source, including second Cited by: 6. Results. Image quality was superior in PC (median image score, 1) in all cases (%) compared with absorption imaging (median image score, 3) (P ; 29 of 29 plaques with lipids, P) with histopathologic Cited by: 8.

Phagocytosis provides an attractive target for molecular imaging of macrophages, because it could lead to the capture FIGURE 1. Simplified schema of di-versity of lesions in human coronary atherosclerosis, depicting 2 morpho-logic extremes of coronary atheroscle-rotic plaques, to illustrate the challenge of molecular imaging of atherosclerosis.

Background Coronary computed tomography angiography (CTA)-verified positive remodeling and low attenuation plaques are considered morphological characteristics of high-risk plaque (HRP) and predict short-term risk of acute coronary syndrome (ACS). Objectives This study evaluated whether plaque characteristics by CTA predict mid-term likelihood of by:   Angioscopy enables us macroscopic pathological diagnosis of cardiovascular diseases from the inside.

This imaging modality has been intensively directed to characterizing vulnerable coronary plaques. Scoring of plaque color was developed, and based on prospective studies, dark yellow or glistening yellow plaques were proposed as vulnerable ones.

Colorimetry apparatus was developed to. Atherosclerotic plaque deposition within the coronary vessel wall leads to arterial stenosis and severe catastrophic events over time. Identification of these atherosclerotic plaque components is essential to pre-estimate the risk of cardiovascular disease (CVD) and stratify them as a high or low risk.

The characterization and quantification of coronary plaque components are not only vital but Cited by: Detection and Quantification of Coronary Atherosclerotic Plaque Using Different Imaging Modalities Mohammad Karimi Moridani Biomedical Engineering Department, Science and Research Branch, Islamic Azad Universit y, Tehran, Iran.

Abstract. The behavior and composition of coronary atherosclerotic plaques are ultimately responsible for the threat. Results. Multicolor CT enabled differentiation of Au-HDL, iodine-based contrast material, and calcium phosphate in the phantoms. Accumulations of Au-HDL were detected in the aortas of the apo E–KO mice, while the iodine-based contrast agent and the calcium-rich tissue could also be detected and thus facilitated visualization of the vasculature and bones (skeleton), respectively, during a Cited by: we evaluated the atherosclerotic plaque images, we successfully performed percutaneous coronary inter-vention without concomitant complication.

This is the first documentation of in vivo molecular imaging of ruptured coronary atherosclerotic plaque by IVUS, OCT, and FDG-PET/CT.

REPRINT REQUESTS AND CORRESPONDENCE: Size: 1MB. and learning strategies for supervised characterization of coronary atherosclerotic plaques.

In my first study, I proposed an approach for calcium quantification in contrast-enhanced examinations of the coronary arteries, potentially eliminating the need for an extra non-contrast X-ray Size: 2MB. Molecular Imaging of the Atherosclerotic Plaque René M. Botnar, PhD Division of Imaging Sciences and Biomedical Coronary Remodeling after Stenting.

Christian von Bary, Circulation Imaging • Imaging biomarkers (albumin, elastin, fibrin) may be also useful for in-vivo. Napkin-Ring Sign. Recently, several studies have described specific attenuation pattern of atherosclerotic plaques on coronary CT images characterized by a plaque core with low CT attenuation surrounded by a rim-like area of higher CT attenuation as napkin-ring sign [79–81].A similar ring-like enhancement was found in plaques with thin-cap fibroatheromas or in patients presenting with Cited by: 9.

or erosion of an atherosclerotic plaque do not experience any prior symptoms. This observation emphasizes the need to improve early detection of atherosclerosis. Tradition-ally, imaging of the coronary arteries has focused on the assessment of luminal dimen-sions and the presence of severe stenosis by means of invasive coronary angiography.

Imaging of coronary artery plaques using contrast-enhanced optical coherence tomography Nicolas Foin. The diagnostic accuracy and assessment of atherosclerotic plaque morphology with OCT remain, however, limited by the rapid attenuation of OCT signal in tissue, limiting contrast on deep plaque structure and accurate assessment of plaque Cited by: CT coronary angiography identified a significant number of coronary plaques in nonstenotic coronary arteries that were underestimated by conventional coronary angiography, according to results of.

Results: Events were observed in % (88/3,) of patients. ACS was observed in % (48/) of patients with HRP versus % (40/2,) of patients without HRP (p. ), and in % (36/) of patients with severe stenosis versus % (52/2,) of patients without severe stenosis (p ).

On multivariable analysis, the presence of severe stenosis without HRP was not associated. Key Words. atherosclerosis; imaging; positron emission tomography; Atherosclerosis remains the leading killer in the U.S.

Inflammation and plaque erosion are the main drivers of clinical events such as myocardial infarction, which usually result from the sudden rupture of macrophage-rich atherosclerotic gh anatomic imaging with X-ray angiography can identify arterial Cited by:   Detection of Lipid Core Coronary Plaques in Autopsy Specimens With a Novel Catheter-Based Near-Infrared Spectroscopy System Craig M.

Gardner, Huwei Tan, Edward L. Hull, Jennifer B. Lisauskas, Stephen T. Sum, Thomas M. Meese, Chunsheng Jiang, Sean P. Madden, Jay D. Caplan, Allen P. Burke, Renu Virmani, James Goldstein, James E. Muller A novel intravascular near-infrared Cited by: INVASIVE IMAGING OF ATHEROSCLEROTIC PLAQUES Invasive coronary angiography Invasive coronary angiography is currently the gold standard for the diagnosis of CAD and provides an accurate and detailed overview of the anatomy of the coronary artery tree, including precise quanti fi cation of the degree of stenosis.

Accordingly, the technique. Studies have shown that vulnerable plaque may be the most important indicator for pdf development of acute coronary pdf, hence the intense interest in a more accurate assessment of noncalcified plaque [].Coronary angiography, the gold standard with respect to treatment, visualizes the lumen, which can increase in size due to vessel remodeling as plaque progresses; therefore, disease Cited by:   SUMMARY: Atherosclerosis remains the leading cause of long-term mortality and morbidity download pdf, despite remarkable advancement in its management.

Vulnerable atherosclerotic plaques are principally responsible for thromboembolic events in various arterial territories such as carotid, coronary, and lower limb vessels. Carotid plaque ulceration is one of the key features Cited by: Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis ebook 18 F positron emission tomography Atherosclerosis is characterized by the formation of complex atheroma lesions (plaques) in arteries that pose risk by their flow-limiting nature .